This review reveals the mechanisms of cancer stem cells' therapy resistance in the tumor microenvironment, suggesting new strategies for targeted treatment.
Key Points
Cancer stem cells drive tumor progression and therapy resistance through unique biological mechanisms.
Key signaling pathways, including Wnt/β-catenin and Hedgehog, regulate cancer stem cell properties and vulnerabilities.
Innovative techniques like single-cell omics enhance the understanding of cancer stem cells in precision medicine applications.
Combining CSC-targeted strategies with existing therapies may improve patient outcomes and prevent relapse.