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August 4, 2025BMC Public HealthOpen Access

Global determinants of breast cancer mortality: a comprehensive meta-analysis of clinical, demographic, and lifestyle risk factors

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Authors

ZDZelalem G. DessieTZTemesgen Zewotir

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Overview

Meta-analysis reveals treatment and socio-demographic factors influence breast cancer mortality in women, indicating the need for tailored interventions.

Key Points

  • Breast cancer remains the leading cause of cancer-related deaths among women globally, with a mortality rate of 16.89%.
  • Analysis of 70 studies and over 2.4 million patients showed that Luminal B subtype increases mortality risk.
  • Factors such as advanced ECOG performance status, HIV positivity, and obesity correlate with higher breast cancer mortality.
  • Higher education levels and effective treatments like lumpectomy with radiation reduce mortality, highlighting the importance of targeted care.

Cite This Study

Dessie et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0f0bhttps://doi.org/10.1186/s12889-025-24036-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond Biology: Uncovering Structural and Sociocultural Predictors of Breast Cancer Incidence Worldwide2025
  2. 2Inequities in breast cancer mortality with contributing cardiometabolic disorders among U.S. women aged ≥45 years, 1999–2024.2026
  3. 3Breast cancer burden (1990–2040) in individuals aged 55 and above: a GBD 2021 analysis of global trends, sex-specific risk factors, and intervention impact2025 · 3 citations
  4. 4Abstract B002: Identifying breast cancer risk factors using comprehensive data from the All of Us research program2025
  5. 5Global burden of cancer in women, 1990–2021: a systematic analysis from the GBD 2021 study2025