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May 30, 2026Journal of Clinical Oncology

Mortality for breast cancer with cardiometabolic contributions among U.S. women ≥45 years increased sharply from 2018–2021 (APC +6.88%, p<0.01), disproportionately affecting Black women.

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Population

167,620 U.S. women aged ≥45 years who died with breast cancer as the underlying cause and cardiometabolic…

Design

Cohort

Follow-up

1999–2024

Key result

Mortality for breast cancer with cardiometabolic contributions among U.S. women ≥45 years increased sharply from 2018–2021 (APC +6.88%, p<0.01), disproportionately affecting Black women.

Authors

MJMian Muinuddin JamshedAZAmna ZaheerMSMariam Shahabi

Discussion

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Overview

Breast cancer mortality with contributing cardiometabolic disorders is rising among U.S. women aged ≥45, with significant racial and geographic disparities highlighting the need for targeted cardio-oncology interventions.

Key Points

  • This analysis aims to characterize trends in breast cancer mortality coupled with cardiometabolic disorders among U.S. women aged ≥45.
  • Analyzed U.S. mortality data from 1999 to 2024 for women aged ≥45 with breast cancer as the underlying cause and cardiometabolic disorders as contributing causes.
  • Calculated age-adjusted mortality rates (AAMR) and utilized joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC).
  • Total of 167,620 deaths among women ≥45 from 1999–2024, with an overall AAMR of 8.40 per 100,000.
  • Mortality among Black women rose significantly from 2015–2024 (APC +3.56%, p < 0.001) with an AAMR of 15.72 in 2024 compared to 9.54 among White women.
  • Nonmetropolitan areas faced alarming trends, especially noncore areas with an APC of +13.35% from 2017 onward.

Study Design

Type

Observational (n=167,620)

Multicenter

Yes

Structured PICO

P
Population
167,620 U.S. women aged ≥45 years who died with breast cancer as the underlying cause and cardiometabolic disorders as contributing causes between 1999 and 2024.
O
Outcome
Age-adjusted mortality rates (AAMR) per 100,000 and Annual Percent Change (APC) in mortalityhard clinical

Main Result

Effect estimate: APC +6.88%

p-value: p=<0.01

Breast cancer mortality with contributing cardiometabolic disorders is rising among U.S. women aged ≥45, with significant racial and geographic disparities highlighting the need for targeted cardio-oncology interventions.

Cite This Study

Jamshed et al. (2026) conducted an observational in Breast cancer with contributing cardiometabolic disorders (n=167,620). Mortality for breast cancer with cardiometabolic contributions among U.S. women ≥45 years increased sharply from 2018–2021 (APC +6.88%, p<0.01), disproportionately affecting Black women.

synapsesocial.com/papers/6a1a82370307b78509433eeehttps://doi.org/10.1200/jco.2026.44.16_suppl.e12704
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and disparities in cardiomyopathy-associated mortality among breast cancer adults aged ≥45 years in the United States, 1999–2023: CDC WONDER analysis.2026
  2. 2Mortality trends among U.S. adults with breast cancer and hypertensive diseases: A nationwide CDC WONDER analysis from 1999 to 2023.2026
  3. 3Mortality involving breast cancer and chronic lower respiratory diseases among postmenopausal women in the United States: A CDC WONDER analysis (1999–2020).2026
  4. 4Shifting burden of cardiomyopathy deaths among United States cancer patients: A 25-year CDC WONDER analysis.2026
  5. 5Temporal and demographic trends in hypertension-associated breast cancer mortality in the United States: A CDC WONDER analysis (1999–2020).2026