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August 4, 2025

Calenduloside E from B. animalis B960 enhances glibenclamide efficacy and alleviates drug-induced side effects via the IRS1/PI3K/AKT pathway in T2D

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Authors

JZJiachao ZhangSSSiyuan ShenLLLiting Lu

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Overview

Probiotic Bifidobacterium animalis improves glibenclamide efficacy and reduces side effects via IRS1/PI3K/AKT signaling.

Key Points

  • Combined Bifidobacterium animalis B960 and glibenclamide therapy significantly reduced blood glucose levels in type 2 diabetes.
  • The coadministration improved insulin sensitivity and increased beneficial metabolite levels in vivo.
  • B960 mitigated glibenclamide-induced side effects like hepatotoxicity and inflammation effectively.
  • The study presents a promising strategy for enhancing diabetes treatment while minimizing drug toxicity.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0ea6https://doi.org/10.21203/rs.3.rs-7088573/v1
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Also Consider

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