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September 11, 2025Journal of Agricultural and Food Chemistry

Bifidobacterium longum subsp. longum B-53 Alleviated Abnormalities of Glycolipid Metabolism and Oxidative Stress in T2DM Mice Through Regulating Gut Microbiota and GLP-1 Secretion

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Authors

JCJingru ChenLZLinfang ZhangZCZhiliang Cheng

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Overview

This study reveals B. longum B-53 enhances glucose homeostasis in T2DM mice, suggesting gut microbiota regulation is crucial for metabolic health.

Key Points

  • B. longum B-53 significantly decreased hemoglobin A1c levels in T2DM mice, indicating improved glucose regulation.
  • The treatment also outperformed metformin by reducing cholesterol levels and systemic inflammation, enhancing overall health.
  • B. longum B-53 was effective in improving intestinal barrier function and reducing oxidative stress, which is vital for T2DM management.
  • Increased GLP-1 secretion and regulation of metabolic pathways were crucial mechanisms behind the beneficial effects of B. longum B-53.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d413ff713b0b5dfea6208chttps://doi.org/10.1021/acs.jafc.5c07346
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Also Consider

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