Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 12, 2025Molecular Medicine Reports

Intestinal CD4+ T cells treated with Pseudostellaria heterophylla polysaccharide improve insulin resistance in BNL CL.2 cells by modulating PI3K/AKT signaling and energy metabolism

View Full Paper
Ask AI
Bookmark
Share

Authors

YKYongjun KanYLYingying LiuYHYating Huang

Discussion

Loading...

Member takes

Overview

Experimental analysis shows improved insulin resistance and PI3K/AKT signaling in IR-BNL CL.2 cells, highlighting metabolic regulation.

Key Points

  • Pseudostellaria heterophylla polysaccharide treatment enhanced insulin sensitivity and reduced oxidative stress in insulin-resistant cells.
  • Key outcomes included increased glucose uptake and decreased apoptosis after treatment with the polysaccharide in BNL CL.2 cells.
  • CD4+ T cells treated with Pseudostellaria polysaccharide activated the PI3K/AKT signaling pathway, regulating energy metabolism effectively.
  • The study suggests a promising therapeutic strategy involving CD4+ T cell modulation to combat insulin resistance in metabolic disorders.

Cite This Study

Kan et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea617dehttps://doi.org/10.3892/mmr.2025.13682
View Full Paper
Ask AI
Bookmark
Share