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August 4, 2025Frontiers in PsychiatryOpen Access

Effectiveness of different therapeutic measures combined with aerobic exercise as an intervention in patients with depression: a systematic review and network meta-analysis

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Authors

LCLei ChenALA. LiJZJia Zhou

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Overview

Systematic review and network meta-analysis demonstrated improved depression scores with combined aerobic exercise interventions, indicating strong efficacy of SSRI+AE and other therapies.

Key Points

  • Combined aerobic exercise interventions are more effective than monotherapy in treating depression.
  • The study included 37 randomized controlled trials with a total of 3,362 patients diagnosed with depression.
  • The strongest therapeutic combination was found to be SSRI combined with aerobic exercise, based on multiple depression scales.
  • Findings highlight the need for further high-quality studies to validate the effectiveness of other aerobic exercise combinations.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f8de6551bb0af8d0d3fhttps://doi.org/10.3389/fpsyt.2025.1573557
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The impact of high-intensity exercise on patients with depression: a systematic review and meta-analysis of randomized controlled trials2025
  2. 2Comparative Effects of Different Types of Exercise Interventions on Depression in Patients With Cancer: A Network Meta‐Analysis of Randomized Controlled Studies2025
  3. 3Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis2025 · 5 citations
  4. 4Effect of nonpharmacologic therapies on depressive symptoms in patients with chronic fatigue syndrome: a network meta-analysis2025
  5. 5Lifestyle Interventions for Depression: An Umbrella Review of Systematic Reviews and Meta-Analyses (Preprint)2025