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August 4, 2025

Aurantiamide Acetate Mitigates Hypertensive Cardiac Hypertrophy via Modulation of MAPK Signaling and ER Stress

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Authors

TÇTuğçe ÇekerMAMutay AslanEKEsma Konuk

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Overview

Cellular experiments showed aurantiamide acetate reduces MAPK activation and cardiac enlargement in H9C2 cells, suggesting its potential in treating hypertensive cardiac hypertrophy.

Key Points

  • Aurantiamide acetate shows promise in reducing hypertensive cardiac hypertrophy by modulating MAPK signaling and ER stress.
  • In vitro tests revealed significant reduction in cardiomyocyte hypertrophy and ER stress markers after treatment with aurantiamide acetate.
  • The study utilized both cellular models and a rat model of hypertrophic cardiomyopathy to evaluate the efficacy of aurantiamide acetate.
  • Results indicate that aurantiamide acetate lowers blood pressure and alleviates cardiac remodeling, demonstrating its therapeutic potential for heart disease.

Cite This Study

Çeker et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0a6ehttps://doi.org/10.21203/rs.3.rs-6939373/v1
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