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August 4, 2025

Optimizing Antibiotic Prophylaxis for Type III Open Fractures in China: A Cost- Effectiveness Analysis

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Authors

STShuo TianLFLei FengZSZhenjun Sun

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Overview

Cost-effectiveness analysis reveals cefazolin as the most effective choice for preventing SSI in type III open fractures, highlighting optimal antibiotic selection.

Key Points

  • CEZ is identified as the most cost-effective regimen for preventing surgical site infections (SSI) in type III open fractures.
  • Assessment compared six antibiotic regimens based on cost and health utility using data from China's drug pricing policy.
  • Sensitivity analyses confirmed the reliability of CEZ as a dominant strategy compared to other antibiotics.
  • Findings support strategic antibiotic selection, optimizing healthcare resources to enhance patient outcomes in surgical care.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d0a38https://doi.org/10.21203/rs.3.rs-7118629/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effectiveness of prophylactic antibiotic regimens in preventing infection in open fractures: a prospective cohort study2025
  2. 2A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures2025
  3. 3Meta-Analysis of Acute Systemic Antimicrobial Prophylaxis (ASAP) for Open Extremity Fracture Management: Subgroup Analysis and Methodological Guidelines2025
  4. 4Cost Effectiveness Analysis of Antibiotics Use Prophylactic in Caesarean Surgery Patients at Dirgahayu Hospital Samarinda2025
  5. 5Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023