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October 2, 2025Open Access

Meta-Analysis of Acute Systemic Antimicrobial Prophylaxis (ASAP) for Open Extremity Fracture Management: Subgroup Analysis and Methodological Guidelines

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Authors

NGNicole A. GriffinAEAaron B. EppersonMAMohamed E. Awad

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Overview

Meta-analysis identifies infection rate comparisons and highlights methodological guidelines for open fractures.

Key Points

  • Flucloxacillin + Benzylpenicillin showed a lower infection rate than Cefazolin + Gentamicin in Type III open fractures.
  • Analysis involved 17 studies with 2,031 patients, focusing on infection rates and hospitalization duration.
  • No single antibiotic prophylactic regimen was determined superior for managing open fractures based on current data.
  • Methodological guidelines were proposed to enhance the robustness of future studies on antimicrobial prophylaxis.

Cite This Study

Griffin et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1b9c2https://doi.org/10.20944/preprints202509.2480.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effectiveness of prophylactic antibiotic regimens in preventing infection in open fractures: a prospective cohort study2025
  2. 2Evidence for Systemic Perioperative Antibiotic Prophylaxis for Prevention of Fracture-related Infections Following Open Fractures: Systematic Review and Meta-Analysis of Randomized, Controlled, Clinical Trials2025
  3. 3Use of Topical Antibiotics in Open Fractures: A Systematic Review and Meta-Analysis2025 · 2 citations
  4. 4A Comparison of Piperacillin-Tazobactam With Conventional Antibiotics for Prophylaxis in Lower Extremity Type III Open Fractures2025
  5. 5Are We on the Same Page? Defining Consensus for Pediatric Open Fracture Management Among Level 1 Pediatric Trauma Centers2025