August 4, 2025

Habenular μ-opioid receptor knockout and chronic systemic receptor blockade promote negative affect and heighten nociceptive sensitivity

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Chronic blockade of μ-opioid receptors increased anxiety-like behaviors and pain sensitivity in mice.
Single administration of the MOR antagonist did not affect baseline behavior, indicating basal μ-opioid tone is not essential.
Knockout of habenular μ-opioid receptors produced similar effects to chronic receptor blockade, emphasizing its importance.
These findings suggest disrupted opioid signaling plays a critical role in mood and pain regulation in the brain.

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Chronic receptor blockade increases anxiety and pain response in mice, highlighting the habenula's role in opioid signaling.

Pekarskaya et al. (2025) studied this question.

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