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September 10, 2025NeuropsychopharmacologyOpen Access

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol

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Authors

RWRoss van de WeteringAAAmy F. AlderABAndrew Biggerstaff

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Overview

Observational analysis reveals beta-arrestin 2's role in antinociception and side effects in mice, suggesting implications for G-protein biased agonists.

Key Points

  • Beta-arrestin 2 signaling does not drive tolerance or side effects of morphine and kurkinorin.
  • Kurkinol showed reduced tolerance after seven days, while all compounds exhibited significant side effects.
  • Mice lacking beta-arrestin 2 displayed increased analgesic potency with morphine and kurkinorin, indicating the signaling's limited role.
  • Findings question the effectiveness of developing G-protein biased compounds to reduce opioid side effects.

Cite This Study

Wetering et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64781fd8https://doi.org/10.1038/s41386-025-02214-z
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1A Biased View of <i>μ</i>-Opioid Receptors?2019 · 115 citations