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July 30, 2025Open Access

Molecular Epidemiology of Infections Caused by Carbapenem-Resistant Pseudomonas aeruginosa and Enterobacterales and Susceptibility of Isolates to Ceftazidime-Avibactam

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Authors

JGJose-Rita GergesSBSara BaradaHHHadi Hussein

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Overview

Phenotypic and genotypic analysis reveals high carbapenem and ceftazidime-avibactam resistance in pathogens, indicating urgent treatment challenges.

Key Points

  • 100% of Klebsiella pneumoniae and 63% of Escherichia coli isolates were carbapenem-resistant.
  • 73% of Klebsiella pneumoniae, 79% of Escherichia coli, and 60% of Pseudomonas aeruginosa were resistant to ceftazidime-avibactam.
  • Whole-genome sequencing identified various sequence types, plasmids, and antimicrobial resistance genes among the isolates.
  • Ceftazidime-avibactam resistance involves multiple factors, including efflux pump overexpression and β-lactamase mutations.

Cite This Study

Gerges et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cf064https://doi.org/10.20944/preprints202507.2149.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Epidemiology of Carbapenem-Resistant P. aeruginosa and Enterobacterales Isolates from Clinical Infections and Their Susceptibility to Ceftazidime–Avibactam2025 · 3 citations
  2. 2Evaluation of Ceftazidime-Avibactam Susceptibility in Carbapenem-Resistant Gram-Negative Bacteria2025
  3. 3Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance2025 · 1 citations
  4. 4Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Multicenter Study in Korea2025 · 4 citations
  5. 5Antimicrobial Resistance Mechanisms in Carbapenem-Resistant Pseudomonas aeruginosa Clinical Strains Isolated in Shanghai, China2025 · 8 citations