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July 15, 2025Frontiers in Cardiovascular MedicineOpen Access

Unraveling mitochondrial crosstalk: a new frontier in heart failure pathogenesis

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Authors

HCHongbo ChangPHPingge HeWLWei‐Di Liu

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Overview

Review details how mitochondrial dysfunction impacts heart failure through organelle interactions, suggesting new therapies.

Key Points

  • Mitochondria are crucial for energy production and signaling in heart cells, linking them to heart failure.
  • Dysfunctional mitochondrial interactions with organelles like the endoplasmic reticulum and lysosomes are tied to heart failure development.
  • The review discusses mitochondrial roles in calcium homeostasis, autophagy, and lipid metabolism in cardiomyocytes.
  • Emerging therapies target organelle networks, providing potential new treatments for heart failure.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc5c6https://doi.org/10.3389/fcvm.2025.1641023
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Also Consider

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  4. 4Oxidative Stress, Mitochondrial Quality Control, Autophagy, and Sirtuins in Heart Failure2025 · 5 citations
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