Genome-wide association studies reveal unique genetic factors influencing substance use across populations, indicating significant genetic correlations with psychiatric disorders.
Key Points
Numerous genes affecting substance use traits were identified, suggesting unique genetic contributions for each type of drug.
Strong genetic correlations were observed between different substance use traits, particularly with opioid use disorder and cannabis use disorder.
Genome-wide association studies were conducted across various ancestries, including European, African, and Latin American populations.
Findings highlight the potential for understanding the biology of substance use, aiding in future risk assessments for drug dependence.