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July 28, 2025

Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

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Authors

JXJihao XuQTQiudi TuLZLi Zhao

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Overview

Experimental study demonstrates AS-IV improves myocardial injury in uremic mice by regulating autophagy, implicating ATF4 and the PI3K pathway.

Key Points

  • AS-IV treatment improved cardiac function and reduced uremia-related cardiomyocyte apoptosis in mouse models.
  • The study employed various techniques, including echocardiography and flow cytometry, to assess myocardial injury and autophagy.
  • Inhibition of ATF4 expression decreased cardiomyocyte apoptosis, highlighting its protective role against myocardial injury.
  • AS-IV was shown to activate the PI3K pathway, suggesting its involvement in autophagy regulation during treatment.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/689a0939e6551bb0af8ce9b0https://doi.org/10.21203/rs.3.rs-7145726/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF42025
  2. 2Astragaloside IV inhibits MAPK pathway and promotes mitochondrial autophagy in rats with heart failure2025
  3. 3The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis2025
  4. 4Astragaloside IV reduces diabetic kidney injury by inhibiting the PKC/NOX4/MAPK pathway2025
  5. 5Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice2025