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December 8, 2025Scientific ReportsOpen Access

Astragaloside IV attenuates uremia-induced myocardial injury by inhibiting autophagy via ATF4

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Authors

QTQiudi TuLZLi ZhaoXYXianyun Ye

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Overview

Experimental treatment with astragaloside IV lowers myocardial injury in uremic conditions, indicating autophagy inhibition via ATF4.

Key Points

  • To investigate the effects of astragaloside IV on myocardial injury associated with uremia and its mechanism of action.
  • Used astragaloside IV treatment in preclinical models of uremia.
  • Assessed myocardial injury levels and autophagy regulation in cardiomyocytes.
  • Examined ATF4 expression and PI3K pathway modulation after treatment.
  • Astragaloside IV treatment significantly reduced myocardial injury associated with uremia.
  • Inhibition of ATF4 expression was observed following treatment with astragaloside IV.
  • The PI3K pathway was implicated in modulating autophagy.

Cite This Study

Tu et al. (2025) studied this question.

synapsesocial.com/papers/693624ad4fa91c937236c54fhttps://doi.org/10.1038/s41598-025-30374-x
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