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September 10, 2025The American Journal of Chinese Medicine

Astragaloside IV Binds with RhoA, Inhibits EndMT and Ameliorates Myocardial Fibrosis in Mice

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Authors

QWQiongsen WangRZRuiqin ZhangNLNan Li

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Overview

In vitro analysis reveals that astragaloside IV inhibits EndMT in HUVECs, impacting myocardial fibrosis in mice.

Key Points

  • ASIV significantly inhibits EndMT, reducing myocardial fibrosis in mice, highlighting its therapeutic potential.
  • The binding affinity of ASIV to RhoA was demonstrated through molecular docking and thermal assays, affirming its role in inhibiting EndMT.
  • Observational analysis utilized TGF-β1 to induce EndMT in HUVECs, alongside Isoproterenol injections for myocardial fibrosis in mice.
  • These findings suggest that ASIV's modulation of the RhoA pathway could be crucial for treating myocardial fibrosis.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478da49https://doi.org/10.1142/s0192415x25500818
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