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July 31, 2025International Journal of Molecular Medicine

How lactate and lactylation shape the immunity system in atherosclerosis (Review)

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Authors

YXYan XiongJZJie ZhouJWJunru Wang

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Overview

Review highlights lactate and lactylation influence immune functions in atherosclerosis, suggesting therapeutic targets.

Key Points

  • Lactate and lactylation act as significant regulators of the immune system in atherosclerosis.
  • The review discusses how lactate affects macrophage polarization and T‑cell differentiation.
  • Key mechanisms include metabolic reprogramming and epigenetic modifications by lactate.
  • Targeting lactate metabolism may lead to new therapies for preventing plaque formation in atherosclerosis.

Cite This Study

Xiong et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf60ahttps://doi.org/10.3892/ijmm.2025.5604
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactylation in Cardiovascular Diseases: Epigenetic Mechanisms and Therapeutic Potential.2025 · 1 citations
  2. 2The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers2025 · 31 citations
  3. 3Lactylation in Cardiovascular Diseases: Current Progress and Perspectives2025
  4. 4Roles of lactylation in lipid metabolism and related diseases2025
  5. 5Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases2025