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July 25, 2025World Journal of Stem Cells

Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases

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Authors

FŞFatma ŞengülÖBÖzlem Bağ

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Overview

Review highlights MSC-derived exosomes' immunomodulatory effects and potential in autoimmune diseases, suggesting new therapeutic avenues.

Key Points

  • MSC-derived exosomes enhance regulatory T cell populations, crucial for managing autoimmune diseases.
  • These exosomes suppress proinflammatory cytokines like tumor necrosis factor-α, linked to inflammation.
  • MSC-Exos improve tissue repair through mechanisms like vascular repair and immune homeostasis restoration.
  • Therapeutic potential extends across multiple autoimmune conditions, including Behçet's disease and systemic lupus erythematosus.

Cite This Study

Şengül et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce19ehttps://doi.org/10.4252/wjsc.v17.i7.107202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases2025
  2. 2From laboratory to clinic: a precise treatment strategy of mesenchymal stem cells-derived exosomes pretreated by simulating disease microenvironment2025 · 7 citations
  3. 3Exosomes: Cutting-Edge Therapies for Autoimmune Dermatologic Diseases2025
  4. 4Multifaceted mechanisms and targeted delivery of mesenchymal stem cell-derived exosomes in cardiovascular diseases: a translational medicine perspective2025 · 1 citations
  5. 5Therapeutic potential of mesenchymal stem cell exosomes for tumors in the digestive system: From bench to bedside2025