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July 23, 2025NutrientsOpen Access

The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses

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Authors

MKMousa KhalafiAMAref Habibi MalekiSMShima Mojtahedi

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Overview

Systematic review shows intermittent fasting reduces certain inflammatory markers in adults, suggesting dietary implications for health.

Key Points

  • Intermittent fasting significantly reduced tumor necrosis factor (TNF-α) by 0.31, showing its potential benefits.
  • The analysis included 21 studies with a total of 839 participants, enhancing the reliability of the findings.
  • Time-restricted feeding (TRF) demonstrated the largest reduction in TNF-α, ranking highest for inflammatory markers.
  • Results suggest that different modes of intermittent fasting can influence inflammatory responses, highlighting dietary variations.

Cite This Study

Khalafi et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdac1https://doi.org/10.3390/nu17152388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time‐Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub‐Study2025
  2. 2Intermittent fasting - its benefits and risks2025
  3. 3The Impact of Ramadan Fasting on Interleukin-6, Tumor Necrosis Factor-α, and C-Reactive Protein in Overweight and/or Obese and Non-Obese Individuals: A Systematic Review with Meta-Analysis2025
  4. 4The effect of intermittent fasting on insulin resistance, lipid profile, and inflammation on metabolic syndrome: a GRADE assessed systematic review and meta-analysis2025
  5. 5The Effects of Time-Restricted Eating and Alternate-Day Modified Fasting on Interferon-γ and Interleukin-10 Levels in Young Asian Women with Obesity: A Quasi-Experimental Study2025