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August 18, 2025Journal of Health Population and NutritionOpen Access

The effect of intermittent fasting on insulin resistance, lipid profile, and inflammation on metabolic syndrome: a GRADE assessed systematic review and meta-analysis

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Authors

LLLing LüXCXi ChenSLShyh Yuh Liou

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Overview

Systematic review shows intermittent fasting improves insulin resistance and lipid profiles in adults, suggesting health benefits for metabolic syndrome.

Key Points

  • Intermittent fasting significantly reduced fasting blood glucose, HbA1c, and HOMA-IR levels in adults, indicating improved glycemic control.
  • The meta-analysis involved eight RCTs with 573 participants, providing robust evidence for the fasting intervention's effects.
  • Fasting also decreased low-density lipoprotein cholesterol and inflammatory markers like IL-6, benefiting overall lipid metabolism.
  • Findings suggest intermittent fasting may enhance cardiometabolic health, underscoring its potential as a therapeutic strategy.

Cite This Study

Lü et al. (2025) studied this question.

synapsesocial.com/papers/68af2ef0cf1dd9ea359e6c29https://doi.org/10.1186/s41043-025-01039-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ROLE OF INTERMITTENT FASTING ON METABOLIC HEALTH IN OVERWEIGHT ADULTS A NARRATIVE REVIEW2025
  2. 2Intermittent fasting - its benefits and risks2025
  3. 3The Impact of Intermittent Fasting on Metabolic and Hormonal Profile in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis2025
  4. 4The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses2025
  5. 5Impacts of Ramadan Fasting on Metabolic and Hepatic Endpoints in Individuals With Metabolic Dysfunction‐Associated Fatty Liver Disease: A Systematic Review and Meta‐Analysis2025