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July 21, 2025Open Access

Gut microbes mediate the synergistic effects of dietary cholesterol and saturated fat in driving fibrosing MASH

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Authors

JHJake B. HermansonSTSamar A. TolbaMGMd. Amran Gazi

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Overview

Research shows dietary cholesterol and saturated fat drive fibrosing MASH in mice, indicating gut microbes play a crucial role.

Key Points

  • Dietary cholesterol and saturated fat are essential for inducing fibrosing mash in SPF mice, while GF mice remain protected.
  • Both dietary cholesterol and saturated fat independently change gut microbial composition, impacting bile acid metabolism.
  • The combination of cholesterol and saturated fat increases Parasutterella spp., which correlates with hepatic fibrosis.
  • Cecal contents from SPF mice fed high-fat diets activate human hepatic stellate cells, linking microbiota to liver fibrogenesis.

Cite This Study

Hermanson et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd4dbhttps://doi.org/10.1101/2025.07.16.665145
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic, Lipidomic, and Enterohormone Changes in the Progression from MASLD to MASH2025
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  4. 4Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease2025 · 5 citations
  5. 5Mediation Analysis of the Molecular Phenotypes in a Severe MASH-like Liver Injury Mouse Model2025