Systematic review assesses vitamin D3 effects on inflammatory markers in overweight youth, suggesting limited impact on CRP and IL-6 but decreased leptin levels.
Key Points
Vitamin D3 supplementation showed no effect on C-reactive protein, interleukin-6, or tumor necrosis factor-α in children.
The review included two randomized controlled trials from a search of 294 citations, highlighting data limitations.
Results indicate a decrease in leptin levels, suggesting some metabolic involvement of vitamin D3.
Current findings stress the need for larger, more comprehensive studies on vitamin D3 effects in overweight youth.