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July 15, 2025International Journal of Molecular SciencesOpen Access

Melatonin as the Missing Link Between Sleep Deprivation and Immune Dysregulation: A Narrative Review

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Authors

ISIda SzataniakKPKacper Packi

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Overview

Narrative review analyzes melatonin's impact on immune function in sleep-deprived individuals, indicating potential therapeutic benefits.

Key Points

  • Melatonin acts as a key mediator in immune function affected by sleep deprivation.
  • Reduced melatonin levels correlate with higher proinflammatory cytokines and lower immune cell activity.
  • The review highlights melatonin's dual role in regulating immune pathways and mitochondrial health.
  • Promoting healthy sleep and melatonin supplementation may help restore immune balance, especially in vulnerable populations.

Cite This Study

Szataniak et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc789https://doi.org/10.3390/ijms26146731
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Also Consider

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  1. 1Melatonin at the Crossroads of Oxidative Stress, Immunity, and Cancer Therapy2026
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  3. 3Melatonin as an anti-inflammatory hormone bridging migraine relief and cancer immunity enhancement: a literature review2025
  4. 4Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin2025 · 27 citations
  5. 5Control and treatment of obesity comorbidities by melatonin nutrological therapy: a systematic review2025