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August 17, 2025Current Issues in Molecular BiologyOpen Access

Circadian Rhythm Disruptions and Cardiovascular Disease Risk: The Special Role of Melatonin

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Authors

JNJarosław NuszkiewiczWRWojciech RzepkaJMJulia Markiel

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Overview

This review highlights how circadian rhythms influence cardiovascular disease risk, suggesting melatonin and chronotherapeutic strategies could improve outcomes.

Key Points

  • Circadian rhythm disruptions raise cardiovascular disease risk, linking sleep irregularity to health concerns.
  • Studies demonstrate that melatonin's antioxidant and anti-inflammatory properties may help mitigate these risks.
  • Narrative review on cardiovascular impacts due to circadian misalignment underscores melatonin's therapeutic potential.
  • Chronotherapeutic strategies, including timed melatonin supplementation, may enhance cardiovascular health and require further exploration.

Cite This Study

Nuszkiewicz et al. (2025) studied this question.

synapsesocial.com/papers/68af33efcf1dd9ea359e94d2https://doi.org/10.3390/cimb47080664
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of circadian-aligned meal timing and sleep rhythm on cardiovascular health: A comprehensive review2025 · 1 citations
  2. 2Circadian regulation of cardiovascular function: from physiology to clinical implications2026
  3. 3Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment2026 · 2 citations
  4. 4FIGHTING THE CLOCK: A LITERATURE-BASED ANALYSIS OF MELATONIN’S THERAPEUTIC ROLE IN SHIFT WORK-RELATED SLEEP DISTURBANCES2025
  5. 5Comprehensive Analysis of the Influences and Regulatory Mechanisms of Circadian Rhythm Genes on Multiple Human Tissues and Organs2025