Oxidative Stress, Mitochondrial Quality Control, Autophagy, and Sirtuins in Heart Failure

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This review discusses oxidative stress, mitochondrial quality control, and autophagy in heart failure, suggesting potential therapeutic pathways.

The interplay between mitochondrial quality control, autophagy, and sirtuins plays a key role in heart failure development, posing challenges for treatment.
Dysfunctional mitochondria enhance oxidative stress and impact autophagy and sirtuins, both of which possess antioxidant properties in heart failure.
This review highlights the dual nature of autophagy, suggesting its complex role may influence outcomes in heart failure related to oxidative stress.
Identifying mutual dependencies among these key components could help in discovering new therapeutic targets for heart failure.

Krekora et al. (2025) studied this question.

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This review discusses oxidative stress, mitochondrial quality control, and autophagy in heart failure, suggesting potential therapeutic pathways.