July 14, 2025Hepatology CommunicationsOpen Access

Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis

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Liver fibrosis involves excessive extracellular matrix deposition caused by activated HSCs during liver injury.
Intercellular communication between hepatocytes and activated HSCs is crucial for liver fibrosis progression.
The review discusses mechanisms like paracrine effects and extracellular vesicles in HSC activation.
Understanding these processes may lead to development of effective antifibrotic therapies.

Authors

RLRuth Y. LanBristol-Myers Squibb (United States)JLJun LinXiamen University SCShuai ChenTongji University

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Implication

Review explores how hepatocytes initiate liver fibrosis by activating HSCs through intercellular communication, suggesting new antifibrotic strategies.

Cite This Study

Lan et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc3bf https://doi.org/10.1097/hc9.0000000000000753

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Implication

Review explores how hepatocytes initiate liver fibrosis by activating HSCs through intercellular communication, suggesting new antifibrotic strategies.

Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis

Key Points

Discussion

Implication

Cite This Study

Communication initiated by hepatocytes: The driver of HSC activation and liver fibrosis

Key Points

Discussion

Implication

Cite This Study

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