Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025mSystemsOpen Access

The diverse phenotypic and mutational landscape induced by fluoroquinolone treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

SMSayed Golam MohiuddinPKPouria KavousiDFDiego Figueroa

Discussion

Loading...

Member takes

Overview

Observational analysis revealed diverse phenotypic outcomes in Escherichia coli under fluoroquinolone stress, suggesting complex resistance mechanisms.

Key Points

  • Tolerance and resistance in Escherichia coli can evolve independently under fluoroquinolone stress, complicating treatment strategies.
  • Cell populations exposed to high-dose ofloxacin developed various mutations, revealing both known and novel genetic adaptations.
  • Whole-genome sequencing identified unique mutations and variable fitness traits without consistent patterns in tolerance and resistance.
  • Findings emphasize the intricate nature of bacterial adaptation, highlighting the role of environmental fluctuations and inter-strain competition.

Cite This Study

Mohiuddin et al. (2025) studied this question.

synapsesocial.com/papers/68c23e94b210217d64792e4ehttps://doi.org/10.1128/msystems.00713-25
View Full Paper
Ask AI
Bookmark
Share