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September 2, 2026Journal of the American Society of Nephrology

ASN Kidney Health Guidance on the Cardiovascular-Kidney-Metabolic Syndrome

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Population

Patients with kidney diseases across the spectrum of severity, including those with…

Design

Guideline

Key result

The Ontario Renal Network outlines best practices for Multi-Care Kidney Clinics to provide person-centered, multidisciplinary care for patients with advanced chronic kidney disease.

Discussion

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Overview

Integrates PREVENT/KFRE stratification and combination SGLT2i/GLP-1/MRA/RASi into CKD practice; establishes new direction by translating recent trials into multidisciplinary guidance.

Structured PICO

P
Population
Patients with advanced chronic kidney disease at high risk of progressing to end-stage kidney disease, eligible for multi-care kidney clinic enrollment.
I
Intervention
Implementation of the cardiovascular-kidney-metabolic (CKM) syndrome framework, including screening, risk stratification (PREVENT and KFRE equations), and pharmacologic management (SGLT2 inhibitors, GLP-1 therapies, nsMRAs, RAS inhibitors, lipid-lowering therapies).

The ASN Kidney Health Guidance outlines a holistic, multidisciplinary approach to managing cardiovascular-kidney-metabolic syndrome in patients with kidney diseases to reduce cardiovascular events and slow kidney disease progression.

Limitations

  • Important gaps remain in applying the CKM framework to patients with advanced CKD, kidney failure treated with dialysis, kidney transplant recipients, younger and older individuals, and those with nonmetabolic kidney diseases including glomerular disorders.

Cite This Study

A 2026 study studied Advanced chronic kidney disease. Multi-Care Kidney Clinic (MCKC) care was evaluated. The Ontario Renal Network outlines best practices for Multi-Care Kidney Clinics to provide person-centered, multidisciplinary care for patients with advanced chronic kidney disease.

synapsesocial.com/papers/6a9a4fc0f9da1bc1819e508fhttps://doi.org/10.1681/asn.0000001231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1From Risk Determinants to Clinical Action2026
  2. 2Evolving strategies for early diagnosis, proactive prevention and treatment of CKD2025 · 12 citations
  3. 3Cardiovascular-kidney-metabolic-syndrome: a modern view of the problem2025
  4. 4Contemporary and Emerging Therapeutics in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: In Memory of Professor Akira Endo2025 · 1 citations
  5. 5Contemporary and Emerging Therapeutics in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: In Memory of Professor Akira Endo2025