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August 28, 2026International Journal of Molecular SciencesOpen Access

Therapeutic Modulation of Nitric Oxide Pathways to Address Insulin Resistance in Cardiovascular–Kidney–Metabolic Syndrome

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Design

Review

Key result

Therapeutic modulation of nitric oxide pathways provides a biologically coherent model for addressing residual cardiometabolic risk, though outcome-level evidence is currently lacking.

Authors

LCLigia-Maria CeterașVBVlad Dumitru BrataIDIoana Dobrotă

Discussion

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Overview

Supports NO pathway targeting in CKM syndrome; extends mechanistic integration across obesity, diabetes, CKD, and CVD.

PICO

P
Population
Cardiovascular-kidney-metabolic (CKM) syndrome
I
Intervention / Comparator
Nitric oxide pathway modulation

Targeting nitric oxide pathway dysfunction offers a potential therapeutic framework to address residual cardiovascular and renal risk in cardiovascular-kidney-metabolic syndrome.

Limitations

  • Direct NO-restoring strategies currently lack outcome-level evidence
  • Biomarkers of NO pathway dysfunction remain insufficiently standardized for clinical use

Cite This Study

Ceteraș et al. (2026) conducted a review in Cardiovascular-kidney-metabolic (CKM) syndrome. Nitric oxide pathway modulation was evaluated. Therapeutic modulation of nitric oxide pathways provides a biologically coherent model for addressing residual cardiometabolic risk, though outcome-level evidence is currently lacking.

synapsesocial.com/papers/6a9950c7555fc9bb8474a4fdhttps://doi.org/10.3390/ijms27177701
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric Oxide Resistance Linked to Vascular and Myocardial Dysfunction in Insulin Resistant Obese Children: A Novel Aortic Strain Study2025
  2. 2Somato-Regulatory Imbalance as a Pathophysiological Basis of Civilization Diseases2025
  3. 3NADPH Oxidase 1 Mediates Endothelial Dysfunction and Hypertension in a Murine Model of Obesity2026
  4. 4Contemporary and Emerging Therapeutics in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: In Memory of Professor Akira Endo2025
  5. 5Contemporary and Emerging Therapeutics in Cardiovascular-Kidney-Metabolic (CKM) Syndrome: In Memory of Professor Akira Endo2025