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July 26, 2026BMC Infectious DiseasesOpen Access

Screening and tuberculosis preventive treatment among household contacts of drug-resistant tuberculosis patients: a scoping review

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Authors

SCSiling ChenLLLan LuoFGFanghua Gong

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Overview

Scoping review synthesizes screening strategies and preventive treatments for household contacts of DR-TB patients, highlighting barriers and gaps.

Key Points

  • This review aims to evaluate evidence regarding screening strategies and preventive treatment regimens for household contacts of drug-resistant tuberculosis patients.
  • Systematic search through nine databases from inception to November 13, 2025.
  • Included observational studies, implementation studies, and randomized controlled trials regarding screening and TPT.
  • Data extraction followed the Joanna Briggs Institute framework and PRISMA-ScR guidelines.
  • Twenty-six studies included, with 20 employing a sequential cascade screening strategy.
  • Levofloxacin-based regimens were predominant, showing higher completion rates compared to combination treatments.
  • Implementation barriers included resource limitations, stigma, and transportation difficulties.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a65a962d3aea3239cd79480https://doi.org/10.1186/s12879-026-14056-1
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