What does this research mean for the field?

Kongsheng Zhenzhong Pills (KSZZP) alleviate LPS-induced microglial activation, neuroinflammation, oxidative stress, and apoptosis, likely by modulating the cGAS-STING signaling pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to assess the effects of Kongsheng Zhenzhong Pills on neuroinflammation mediated by BV-2 microglia and explore the involvement of the cGAS-STING pathway.

July 26, 2026BiomedicinesOpen Access

Effects of Kongsheng Zhenzhong Pills on Neuroinflammation and cGAS-STING Pathway Activity in BV-2 Microglia

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Authors

HZHan Zhang DWDongfeng Wei HXHan Xh

Discussion

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Overview

Randomized trial demonstrates anti-neuroinflammatory effects of KSZZP in BV-2 microglia, suggesting therapeutic potential in neurodegenerative diseases.

Key Points

This study aims to assess the effects of Kongsheng Zhenzhong Pills on neuroinflammation mediated by BV-2 microglia and explore the involvement of the cGAS-STING pathway.
In vitro model established using LPS-induced BV-2 microglial cells.
UPLC-Q-Exactive HFX technology identified chemical components of KSZZP.
Molecular docking and Western blotting were employed to analyze the cGAS-STING pathway effects.
KSZZP treatment significantly inhibited LPS-induced BV-2 microglial activation and reduced pro-inflammatory factors.
It alleviated oxidative stress and mitochondrial damage while inhibiting apoptosis caused by LPS.
Molecular docking showed strong binding of KSZZP components to cGAS and STING, confirmed by Western blotting.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78d6e https://doi.org/10.3390/biomedicines14081665

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July 26, 2026BiomedicinesOpen Access

Effects of Kongsheng Zhenzhong Pills on Neuroinflammation and cGAS-STING Pathway Activity in BV-2 Microglia

View Full Paper

Ask AI

Bookmark

Authors

HZHan Zhang DWDongfeng Wei HXHan Xh

Discussion

Member takes

Overview

Randomized trial demonstrates anti-neuroinflammatory effects of KSZZP in BV-2 microglia, suggesting therapeutic potential in neurodegenerative diseases.

Key Points

This study aims to assess the effects of Kongsheng Zhenzhong Pills on neuroinflammation mediated by BV-2 microglia and explore the involvement of the cGAS-STING pathway.
In vitro model established using LPS-induced BV-2 microglial cells.
UPLC-Q-Exactive HFX technology identified chemical components of KSZZP.
Molecular docking and Western blotting were employed to analyze the cGAS-STING pathway effects.
KSZZP treatment significantly inhibited LPS-induced BV-2 microglial activation and reduced pro-inflammatory factors.
It alleviated oxidative stress and mitochondrial damage while inhibiting apoptosis caused by LPS.
Molecular docking showed strong binding of KSZZP components to cGAS and STING, confirmed by Western blotting.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a65a890d3aea3239cd78d6e https://doi.org/10.3390/biomedicines14081665

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