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July 24, 2026Journal of the National Comprehensive Cancer Network

Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia

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Authors

FCFang ChengYWYu WangZYZhu Y

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Overview

Randomized trial defines conditions for treatment discontinuation in chronic myeloid leukemia, indicating safe monitoring strategies.

Key Points

  • This study aims to establish the conditions under which patients with chronic myeloid leukemia can safely discontinue treatment and predict outcomes.
  • Collected data from 802 cases of tyrosine kinase inhibitor discontinuation across 11 centers.
  • Focused on patients with chronic myeloid leukemia who maintained a deep molecular response for at least two years.
  • Developed predictive models and a web-based calculator for clinical decision-making.
  • 318 out of 698 eligible patients (45.6%) lost major molecular response within 12 months, mostly in the first 6 months.
  • TFR rates were 66.5% at 6 months, 57.7% at 12 months, and 55.5% at 24 months after discontinuation.
  • Patients with longer TKI treatment duration and sustained deep molecular responses had higher TFR rates, validated by predictive models.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a62ffef395161722cd1525bhttps://doi.org/10.6004/jnccn.2026.7026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of successful tirosine kinase inhibitor discontinuation in chronic myeloid leukemia: Long-term, real-world evidence on the role of faster molecular decline and duration of response2025
  2. 2TKI Use and Treatment-Free Remission in Chronic Myeloid Leukemia: Evidence from a Regional Cohort Study in the Canary Islands2025
  3. 3Predictive factors for successful treatment-free remission in patients with chronic myeloid leukemia: A pooled analysis2025
  4. 4Treatment-free remission in patients with chronic myeloid leukemia following the second discontinuation of tyrosine kinase inhibitors2025
  5. 5An evaluation of a real-world, multi-disciplinary, treatment-free remission programme for patients with Chronic Myeloid Leukaemia2025