Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 23, 2026Circulation Genomic and Precision Medicine

Genetic Associations With Carotid Intima-Media Thickness in the Chinese Population and Shared Genetic Architecture With Cardiometabolic Diseases and Traits

View Full Paper
Ask AI
Bookmark
Share

Key result

Higher SBP, BMI, CAD, and T2D are genetically linked to increased cIMT.

  • n=22,370

Population

22,370 participants from the China Kadoorie Biobank (Chinese population)

Design

Other

Authors

WWWenxiu WangKing UniversityNHNinghao HuangPeking UniversityCYCanqing YuBroad Institute

Discussion

Loading...

Member takes

Implication

Novel cIMT loci identified in non-Europeans; extends European GWAS but leaves clinical translation open.

Key Points

  • This research aims to identify genetic variants associated with carotid intima-media thickness (cIMT) in the Chinese population and examine its genetic relationships with cardiometabolic diseases.
  • Conducted a genome-wide association study with 22,370 participants from the China Kadoorie Biobank.
  • Performed linkage disequilibrium score regression and genome-wide cross-trait analysis to uncover genetic correlations.
  • Utilized Mendelian randomization to explore causal relationships between cIMT and cardiometabolic traits.
  • cIMT showed significant genetic correlations with coronary artery disease, type 2 diabetes, body mass index, and systolic blood pressure.
  • Identified 110 significant pleiotropic variants in East Asians, with 27 colocalized loci, compared to 699 and 186 in Europeans.
  • Mendelian randomization suggested that higher systolic blood pressure and body mass index are causal for increased cIMT, with reciprocal effects noted.

Study Design

Type

Observational (n=22,370)

Multicenter

Yes

Structured PICO

P
Population
22,370 participants from the China Kadoorie Biobank analyzed to identify genetic variants associated with carotid intima-media thickness and shared genetic architecture with cardiometabolic traits.
O
Outcome
Genetic variants associated with carotid artery intima-media thickness (cIMT)surrogate

This large-scale GWAS identified novel genetic loci for cIMT in a Chinese population and demonstrated shared genetic architecture and causal relationships between cIMT and cardiometabolic traits.

Cite This Study

Wang et al. (2026) conducted an observational in Carotid artery intima-media thickness (n=22,370). Cardiometabolic diseases and traits was evaluated on Genetic associations and causal relationships with cIMT. Mendelian randomization indicated that higher systolic blood pressure, body mass index, coronary artery disease, and type 2 diabetes were causally associated with carotid intima-media thickness.

synapsesocial.com/papers/6a61afaefaa9903c5116a673https://doi.org/10.1161/circgen.125.005542
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association Between Cardiometabolic Index and Carotid Intima-Media Thickness in Patients With Lacunar Stroke2025
  2. 2C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population2025 · 3 citations
  3. 3Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular Mortality2025 · 3 citations
  4. 4The interconnections between novel adiposity indices and cardiometabolic multimorbidity in Chinese adults: a population-based cross-sectional study2026
  5. 5Assessment of the Association Between Cardiac Metabolic Markers and Carotid Atherosclerosis, and the Role of Insulin Resistance2025 · 1 citations