October 9, 2025Hypertension

Blood Pressure Genetics in Han Taiwanese With Cross-Trait Analysis in East Asians: Insights Into Comorbidities, All-Cause Mortality, and Cardiovascular Mortality

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Large-scale analysis reveals genetic links to hypertension and mortality in East Asians, highlighting implications for risk assessment.

Strong genetic associations with blood pressure traits were identified, impacting risks of comorbidities and mortality.
Eight loci and 36 genes were linked to hypertension, demonstrating the complex genetic architecture of blood pressure.
Mendelian randomization revealed that elevated blood pressure causally increases the risk of unstable angina pectoris.
This analysis emphasizes the importance of genetic risk in guiding future hypertension prevention strategies.

Lin et al. (2025) studied this question.

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