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July 23, 2026Journal of Clinical MedicineOpen Access

Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury—A Retrospective Cohort Study Based on the MIMIC-IV Database

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Authors

JWJia WanCZChaoqun ZhangKLKuncan Lin

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Overview

Retrospective cohort study finds prognostic nutritional index predicts higher mortality in surgical sepsis patients with AKI, indicating potential clinical use.

Key Points

  • The study aims to assess the prognostic value of the prognostic nutritional index in predicting 90-day mortality among patients with surgical sepsis and acute kidney injury.
  • Retrospective cohort study using the MIMIC-IV database from 2008 to 2022.
  • Included adult ICU patients meeting Sepsis-3 criteria with AKI as per KDIGO guidelines.
  • Analyzed the association between PNI and 90-day mortality using Cox proportional hazards models and Kaplan–Meier analysis.
  • Included 1483 patients with a 90-day mortality rate of 30.2%.
  • Each 1-point increase in PNI correlated with a 1.5% reduction in 90-day mortality (HR 0.985, 95% CI 0.974–0.997, p=0.012).
  • Patients with low PNI had significantly lower 90-day survival compared to those with high PNI (log-rank p < 0.0001).

Cite This Study

Wan et al. (2026) studied this question.

synapsesocial.com/papers/6a61aeeefaa9903c5116a00ahttps://doi.org/10.3390/jcm15145706
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