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September 10, 2025Frontiers in NutritionOpen Access

The V-shaped association between the ratio of neutrophil counts to prognostic nutritional index and 30-, 60-, and 90-day mortality in elderly critically ill patients aged 65 and older with sepsis: a retrospective study based on the MIMIC database

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Authors

JCJierui CaiYJYifeng JinJLJiaqi Lou

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Overview

Retrospective study revealed a significant association between neutrophil counts and mortality risk in elderly sepsis patients, suggesting clinical utility.

Key Points

  • Higher neutrophil counts in elderly patients were associated with increased mortality risk over 30, 60, and 90 days.
  • Kaplan–Meier survival analysis indicated lower survival rates in extreme quartiles of neutrophil counts (Q1 and Q4) across all time frames.
  • Cox regression further confirmed significant associations of neutrophil counts as a continuous variable and in higher quartiles.
  • The dual risks of immunonutritional depletion and hyperinflammation underscore the clinical relevance of the prognostic nutritional index.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64782cdchttps://doi.org/10.3389/fnut.2025.1602016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between neutrophil percentage-to-albumin ratio and all-cause mortality in patients with sepsis: A retrospective cohort study2025
  2. 2Predictive Value of the Neutrophil-to-Lymphocyte Ratio for 28-Day Mortality in Elderly Patients with Sepsis: A Cohort Study Based on the MIMIC-IV Database2025
  3. 3Association between NUTRIC score and ICU mortality in patients with sepsis: a prospective cohort study2025
  4. 4Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury—A Retrospective Cohort Study Based on the MIMIC-IV Database2026
  5. 5Association between prognostic nutritional index and all-cause mortality in critically ill patients with ventilator-associated pneumonia: a retrospective study based on MIMIC-IV database2025