What is the clinical evidence from this study?

Study design: Observational. Population: Heart failure with preserved ejection fraction (HFpEF) in sinus rhythm (n=726). Intervention: Elevated resting heart rate (≥75 bpm) vs. Lower resting heart rate (≤63 bpm). Primary outcome: All-cause mortality (HR 2.10, 95% CI 1.33-3.32, p=0.001).

What does this research mean for the field?

Elevated resting heart rate (≥75 bpm) is an independent predictor of increased all-cause mortality in HFpEF patients in sinus rhythm, even after adjusting for associated factors like inflammation and malnutrition. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to explore the relationship between elevated heart rate and mortality in heart failure patients in sinus rhythm.

July 19, 2026European Heart JournalOpen Access

Elevated resting heart rate (≥75 bpm) was independently associated with increased all-cause mortality compared to lower heart rate (≤63 bpm) in HFpEF patients in sinus rhythm (HR 2.10; 95% CI 1.33-3.32; p=0.001).

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Why the study?

Does elevated resting heart rate predict all-cause mortality in patients with HFpEF in sinus rhythm?

Population

726 patients in sinus rhythm with heart failure with preserved ejection fraction from a prospective…

Comparison

Elevated resting heart rate vs Lower resting heart rate (Tertile 1: HR ≤63 bpm)

Design

Cohort

Follow-up

median 598 days (interquartile range 329–1028 days)

Key result

Elevated resting heart rate (≥75 bpm) was independently associated with increased all-cause mortality compared to lower heart rate (≤63 bpm) in HFpEF patients in sinus rhythm (HR 2.10; 95% CI 1.33-3.32; p=0.001).

Authors

YNY Nakagawa MSM Sairyo KMK Miyazawa

Discussion

Member takes

Overview

T3 linked to higher mortality in this cohort; hypothesis-generating and requires prospective validation before clinical use.

Key Points

This study aims to explore the relationship between elevated heart rate and mortality in heart failure patients in sinus rhythm.
Prospective multicenter observational study of 1161 patients with HFpEF, examining 726 patients in SR.
Laboratory tests and echocardiography were conducted; resting heart rate analyzed in tertiles.
Patients followed for a median of 598 days to observe all-cause mortality outcomes.
Kaplan analysis showed a significant difference between heart rate and mortality (p=0.001).
Multivariable Cox regression revealed T3 (HR ≥75) independently associated with mortality (HR: 2.10, 95% CI: 1.33–3.32, p=0.001).
C-reactive protein was higher and nutritional risk index lower in high heart rate group (p=0.0004 and p=0.001, respectively).

Study Design

Type

Observational (n=726)

Multicenter

Yes

Structured PICO

Does elevated resting heart rate predict all-cause mortality in patients with HFpEF in sinus rhythm?

Population

726 patients with HFpEF in sinus rhythm, evaluated in the compensated stage, followed for a median of 598 days.

Exposure

Elevated resting heart rate (Tertile 3: HR ≥75 bpm)

Comparator

Lower resting heart rate (Tertile 1: HR ≤63 bpm)

Outcome

All-cause mortalityhard clinical

Main Result

Hazard Ratio: 2.1 (95% CI 1.33–3.32)

p-value: p=0.001

Elevated resting heart rate (≥75 bpm) is an independent predictor of all-cause mortality in patients with HFpEF in sinus rhythm, even after adjusting for inflammation and malnutrition.

Cite This Study

Nakagawa et al. (2022) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) in sinus rhythm (n=726). Elevated resting heart rate (≥75 bpm) vs. Lower resting heart rate (≤63 bpm) was evaluated on All-cause mortality (HR 2.10, 95% CI 1.33-3.32, p=0.001). Elevated resting heart rate (≥75 bpm) was independently associated with increased all-cause mortality compared to lower heart rate (≤63 bpm) in HFpEF patients in sinus rhythm (HR 2.10; 95% CI 1.33-3.32; p=0.001).

synapsesocial.com/papers/6a5c4226f18ae74a40a674be https://doi.org/10.1093/eurheartj/ehac544.772

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July 19, 2026European Heart JournalOpen Access

Elevated resting heart rate (≥75 bpm) was independently associated with increased all-cause mortality compared to lower heart rate (≤63 bpm) in HFpEF patients in sinus rhythm (HR 2.10; 95% CI 1.33-3.32; p=0.001).

View Full Paper

Ask AI

Bookmark

Why the study?

Does elevated resting heart rate predict all-cause mortality in patients with HFpEF in sinus rhythm?

Population

726 patients in sinus rhythm with heart failure with preserved ejection fraction from a prospective…

Comparison

Elevated resting heart rate vs Lower resting heart rate (Tertile 1: HR ≤63 bpm)

Design

Cohort

Follow-up

median 598 days (interquartile range 329–1028 days)

Key result

Authors

YNY Nakagawa MSM Sairyo KMK Miyazawa

Discussion

Member takes

Overview

T3 linked to higher mortality in this cohort; hypothesis-generating and requires prospective validation before clinical use.

Key Points

This study aims to explore the relationship between elevated heart rate and mortality in heart failure patients in sinus rhythm.
Prospective multicenter observational study of 1161 patients with HFpEF, examining 726 patients in SR.
Laboratory tests and echocardiography were conducted; resting heart rate analyzed in tertiles.
Patients followed for a median of 598 days to observe all-cause mortality outcomes.
Kaplan analysis showed a significant difference between heart rate and mortality (p=0.001).
Multivariable Cox regression revealed T3 (HR ≥75) independently associated with mortality (HR: 2.10, 95% CI: 1.33–3.32, p=0.001).
C-reactive protein was higher and nutritional risk index lower in high heart rate group (p=0.0004 and p=0.001, respectively).

Study Design

Type

Observational (n=726)

Multicenter

Yes

Structured PICO

Does elevated resting heart rate predict all-cause mortality in patients with HFpEF in sinus rhythm?

Population

726 patients with HFpEF in sinus rhythm, evaluated in the compensated stage, followed for a median of 598 days.

Exposure

Elevated resting heart rate (Tertile 3: HR ≥75 bpm)

Comparator

Lower resting heart rate (Tertile 1: HR ≤63 bpm)

Outcome

All-cause mortalityhard clinical

Main Result

Hazard Ratio: 2.1 (95% CI 1.33–3.32)

p-value: p=0.001

Elevated resting heart rate (≥75 bpm) is an independent predictor of all-cause mortality in patients with HFpEF in sinus rhythm, even after adjusting for inflammation and malnutrition.

Cite This Study

synapsesocial.com/papers/6a5c4226f18ae74a40a674be https://doi.org/10.1093/eurheartj/ehac544.772

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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