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June 12, 2026European Journal of Preventive CardiologyOpen Access

In advanced heart failure, two-year mortality was 45.74%, and stable NT-proBNP, lymphocyte percentage (p=0.0004), and LDL-cholesterol (p=0.04) were significantly associated with death.

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Key result

In advanced heart failure, two-year mortality was 45.74%, and stable NT-proBNP, lymphocyte percentage (p=0.0004), and LDL-cholesterol (p=0.04) were significantly associated with death.

Authors

MKM KouremetiVKV KouloliaEAE Agrotis

Discussion

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Overview

Retrospective observational study identifies key mortality factors in patients with heart failure, suggesting critical risk stratification needs.

Key Points

  • Identify clinical and biochemical factors associated with mortality in patients with acute heart failure.
  • Retrospective observational study of 647 patients with heart failure (NYHA Class III-IV) hospitalized in 2022.
  • Factors assessed included demographics, hospitalization history, specific interventions, and biochemical markers.
  • Two-year follow-up to record mortality rates and correlations with various clinical factors.
  • Overall mortality rate was 45.74% with 296 deaths recorded during follow-up.
  • Significant associations found between mortality and factors like ischemic heart disease, significant valvular disease (55% mortality), and stable NT-proBNP levels (p=0.0004).
  • Lack of change in NT-proBNP and lymphocyte percentage are statistically significant predictors of mortality (p=0.0004 and p=0.04 respectively).

Study Design

Type

Observational (n=647)

PICO

P
Population
647 patients with advanced heart failure (NYHA Class III-IV) hospitalized for new or worsening symptoms, followed for two years.
E
Exposure / Comparator
Clinical and biochemical factors
O
Primary Outcome
mortality

Cite This Study

Kouremeti et al. (2026) conducted an observational in heart failure (NYHA Class III-IV) (n=647). Clinical and biochemical factors was evaluated on mortality. In advanced heart failure, two-year mortality was 45.74%, and stable NT-proBNP, lymphocyte percentage (p=0.0004), and LDL-cholesterol (p=0.04) were significantly associated with death.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe873https://doi.org/10.1093/eurjpc/zwag249.055
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