What question did this study set out to answer?

The aim is to investigate how S100A4 influences collective invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC).

S100A4 promotes collective invasion of pancreatic ductal adenocarcinoma and its blockade suppresses metastasis

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Randomized trial explores S100A4's role in collective invasion in pancreatic ductal adenocarcinoma, indicating a new therapeutic target.

The aim is to investigate how S100A4 influences collective invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC).
Developed a 3D collective invasion model using PDAC cells and pancreatic stellate cells (PSCs) co-culture spheroids.
Utilized S100A4 knockdown and overexpression to evaluate impacts on invasion and migration.
Applied AI-guided structure modeling to create S100A4-targeting inhibitory peptides.
S100A4 knockdown reduced collective invasion and trans-endothelial migration, while S100A4 overexpression enhanced these processes.
Depletion of S100A4 significantly decreased tumor aggressiveness and metastasis in an orthotopic pancreatic tumor model.
S100A4 promotes LAMB3 expression in PSCs, facilitating PDAC invasiveness.

Son et al. (2026) studied this question.

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