July 22, 2025

S100 genes drive metastasis in salivary gland carcinoma

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Comparative analysis reveals S100 oncogenes drive metastasis in salivary gland carcinoma, suggesting therapeutic potential.

S100 genes are crucial drivers of aggressive behavior and metastasis in salivary gland carcinoma.
Salivary duct carcinoma exhibits higher metastatic potential than adenoid cystic carcinoma due to S100 gene upregulation.
Functional studies show that S100 overexpression enhances tumor cell proliferation, migration, and EMT characteristics.
S100 proteins could serve as prognostic biomarkers and therapeutic targets in high-grade salivary gland carcinoma.

Lee et al. (2025) studied this question.

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