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July 11, 2026Clinical Transplantation and ResearchOpen Access

Prophylactic interventions for focal segmental glomerulosclerosis recurrence after kidney transplantation: a systematic review and network meta-analysis

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Authors

TPThemistoklis ParaskevasAKAnna KantaPPPanagiota Perdiki

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Overview

Systematic review evaluates interventions to prevent recurrent FSGS after kidney transplant, indicating inconclusive outcomes.

Key Points

  • The aim is to evaluate and compare the efficacy and safety of prophylactic interventions for preventing recurrent FSGS after kidney transplantation.
  • Conducted a systematic review and network meta-analysis of randomized and nonrandomized studies
  • Included patients with primary FSGS undergoing kidney transplantation
  • Search conducted on PubMed and Embase through July 2025.
  • Twenty-five studies evaluated six interventions, with no significant reduction in FSGS recurrence compared to control
  • Combination of rituximab and plasma exchange showed lower effect estimates, but not statistically significant
  • Adverse events reported infrequently, indicating limited safety concerns.

Cite This Study

Paraskevas et al. (2026) studied this question.

synapsesocial.com/papers/6a51ddbfc18d7f28ca50010chttps://doi.org/10.4285/ctr.25.0102
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recurrence of Glomerular Diseases (GN) After Kidney Transplantation: A Narrative Review2025
  2. 2Treatment Response Rates and Kidney Outcomes among Adults with Primary Focal Segmental Glomerulosclerosis2025
  3. 3Role of Nuclear Scan in a Patient With Recurrent Focal Segmental Glomerulosclerosis Post-Transplantation: A Case Report2025
  4. 4Efficacy of rituximab in refractory focal segmental glomerulosclerosis2025
  5. 5Paediatric Focal Segmental Glomerulosclerosis (FSGS): From Bench to Bedside and Beyond2025