Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 3, 2026Circulation Cardiovascular Imaging

Emotional TTS triggers are linked to ~20% greater myocardial edema, while secondary TTS features more LGE.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the triggering factor and classification of Takotsubo syndrome influence the myocardial tissue response as assessed by cardiovascular magnetic resonance imaging?

Population

110 patients with Takotsubo syndrome from the InterTAK registry who underwent cardiovascular magnetic…

Design

Cohort

Key result

Emotional triggers in Takotsubo syndrome were associated with larger myocardial edema (72% vs 60%; P<0.01), whereas secondary TTS had more frequent late gadolinium enhancement (54% vs 19%; P<0.01).

Authors

AGAlexander GotschyVCVictoria L. CammannVSV Schweiger

Discussion

Loading...

Member takes

Overview

Emotional triggers linked to greater edema and secondary TTS to more LGE on CMR; extends pathophysiologic insights but leaves open management implications.

Key Points

  • This study aims to explore the differences in myocardial tissue response in Takotsubo syndrome based on trigger types.
  • Multicenter cohort study including 110 patients from the InterTAK registry
  • Cardiovascular magnetic resonance imaging measured left ventricular function, myocardial edema, and late gadolinium enhancement
  • Participants underwent imaging 3 days after symptom onset
  • Emotional triggers resulted in larger myocardial edema (72% vs 60%, P < 0.01)
  • Secondary TTS showed a higher prevalence of late gadolinium enhancement (54% vs 19%, P < 0.01)
  • Only emotional trigger and absence of coronary artery disease were linked to extensive myocardial edema (P < 0.01 and P = 0.04, respectively)

Study Design

Type

Cohort (n=110)

Multicenter

Yes

Structured PICO

Does the triggering factor and classification of Takotsubo syndrome influence the myocardial tissue response as assessed by cardiovascular magnetic resonance imaging?

P
Population
110 patients (95% female, mean age 66 years) with Takotsubo syndrome from the InterTAK registry who underwent cardiovascular magnetic resonance imaging early after symptom onset.
O
Outcome
Left ventricular function, myocardial edema, and myocardial injury (late gadolinium enhancement) assessed by cardiovascular magnetic resonance imaging.surrogate

Main Result

Absolute Event Rate: 72% vs 60%

p-value: p=<0.01

Cardiovascular magnetic resonance imaging reveals that emotionally triggered Takotsubo syndrome is associated with greater myocardial edema, whereas secondary Takotsubo syndrome is more frequently associated with direct myocardial damage evidenced by late gadolinium enhancement.

Cite This Study

Gotschy et al. (2026) conducted a cohort in Takotsubo syndrome (n=110). Emotional triggers vs. Physical triggers was evaluated on Extent of myocardial edema (p=<0.01). Emotional triggers in Takotsubo syndrome were associated with larger myocardial edema (72% vs 60%; P<0.01), whereas secondary TTS had more frequent late gadolinium enhancement (54% vs 19%; P<0.01).

synapsesocial.com/papers/6a4752775c29257aa2579253https://doi.org/10.1161/circimaging.125.019335
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Microvascular Dysfunction in Stress Cardiomyopathy: At the Heart of the Problem2026
  2. 2Takotsubo syndrome: Unraveling the mystery behind its triggers (Review)2025 · 5 citations
  3. 3Takotsubo Cardiomyopathy: An Exploration of the Intersection Between Stress, Coronary Dysfunction, and Cardiac Outcomes2025
  4. 4Takotsubo syndrome in the context of pre-existing non-ischemic cardiomyopathy: mechanistic and clinical implications2026
  5. 5Intracranial Triggers of Takotsubo Syndrome2025