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June 28, 2026SchizophreniaOpen Access

Stressful life events and their association with symptom severity and functioning in first-episode psychosis

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Authors

STStefania TogninМММарія МорозAAAljawharah Almuqrin

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Overview

Randomized trial examines symptom severity, functioning, and relapse in first-episode psychosis, suggesting the need for early intervention strategies.

Key Points

  • This study aims to evaluate the impact of stressful life events on symptom severity and functioning in individuals experiencing first-episode psychosis.
  • Longitudinal data analysis from the social mind study (ISRCTN85485447) involving 265 first-episode psychosis participants.
  • Assessment of associations between baseline stressful life events and clinical outcomes over a 1-year follow-up.
  • Statistical models adjusted for age, sex, ethnicity, and site.
  • Greater baseline exposure to stressful life events predicted more severe general psychopathology at follow-up (p < 0.05).
  • Higher baseline stressful life events correlated with poorer functioning across assessment timepoints (p < 0.05).
  • No significant association found between baseline stressful life events and increased odds of relapse.

Cite This Study

Tognin et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c698ehttps://doi.org/10.1038/s41537-026-00778-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between childhood trauma and social vulnerability in adulthood in patients with first episode psychosis2025
  2. 2The impact of socioeconomic factors on the incidence and characteristics of first-episode psychosis2025 · 1 citations
  3. 3The Moderating Role of Psychological Well‐Being in the Relation Between Stressful Life Events and Common Mental Disorders in the General Population2025
  4. 4Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study2025
  5. 5mRNA levels of HPA axis mediators in drug-naïve, first episode psychosis patients before and after antipsychotic treatment2025