Can Polygenic Risk Scores for Metabolic Syndrome Contribute to Long-Term Syndrome Development in First-Episode Psychosis Patients? A Naturalistic 21-Year Follow-Up Study

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A 21-year follow-up study shows polygenic risk scores predict metabolic syndrome in first-episode psychosis, suggesting new clinical pathways.

Polygenic risk scores for metabolic syndrome contributed to long-term metabolic disturbances in first-episode psychosis.
At follow-up, these scores accounted for 7.9% of the variance in metabolic syndrome development and 6.8% for waist circumference increase.
The study utilized logistic regression models and network analysis to examine relationships between risk scores and metabolic symptoms.
Findings indicate polygenic risk scores might help clinicians identify vulnerable patients at risk for metabolic syndrome.

Cuesta et al. (2025) studied this question.

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A 21-year follow-up study shows polygenic risk scores predict metabolic syndrome in first-episode psychosis, suggesting new clinical pathways.