Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 27, 2026EP EuropaceOpen Access

Pulsed-field ablation is linked to ~59% lower arrhythmic recurrence versus radiofrequency ablation.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does electroporation (pulsed-field ablation) reduce clinical arrhythmia recurrence compared to radiofrequency ablation in patients with left atrial macroreentrant flutter post-AF ablation?

Population

89 patients with left atrial macroreentrant flutter that appeared after or during an atrial fibrillation…

Comparison

Electroporation (pulsed-field ablation) (n=39) vs Radiofrequency ablation (n=50)

Design

Cohort

Follow-up

6 months and final follow-up (exact duration not specified)

Key result

Electroporation (pulsed-field ablation) significantly reduced arrhythmic recurrence at final follow-up compared to radiofrequency ablation (17.9% vs 44.0%, p=0.008).

Authors

CMC Arveras MartinezMFM T Izquierdo De FranciscoJMJ Navarro Manchon

Discussion

Loading...

Member takes

Overview

PFA may be associated with lower recurrence than RF; hypothesis-generating, requiring randomized confirmation before practice change.

Key Points

  • The aim is to evaluate the efficacy and safety of electroporation for left atrial flutter management and compare it with radiofrequency ablation.
  • Ambispective observational study including 89 patients with left atrial flutter after AF ablation.
  • Radiofrequency was used in 50 patients, while 39 patients underwent pulsed-field ablation.
  • Survival analysis performed using Kaplan-Meier method with differences assessed via log-rank test.
  • Arrhythmia recurrence at 6 months was 31% for RF patients versus 12.8% for PFA patients (p < 0.05).
  • Final follow-up showed recurrence rates of 44% in RF vs 17.9% in PFA (p = 0.008).
  • Improved flutter-free survival in PFA group demonstrated with p = 0.015.

Study Design

Type

Observational (n=89)

Multicenter

No

Structured PICO

Does electroporation (pulsed-field ablation) reduce clinical arrhythmia recurrence compared to radiofrequency ablation in patients with left atrial macroreentrant flutter post-AF ablation?

P
Population
89 patients with left atrial macroreentrant flutter following atrial fibrillation ablation, treated with either electroporation or radiofrequency ablation.
E
Exposure
Electroporation (pulsed-field ablation) (n=39)
C
Comparator
Radiofrequency ablation (n=50)
O
Outcome
Clinical arrhythmic recurrence (including atrial fibrillation and left atrial flutter) at 6 months and final follow-upcomposite

Main Result

Absolute Event Rate: 17.9% vs 44%

p-value: p=0.008

Pulsed-field ablation is associated with significantly lower rates of arrhythmic recurrence and improved flutter-free survival compared to radiofrequency ablation for left atrial macroreentrant flutter.

Cite This Study

Martinez et al. (2026) conducted an observational in Left atrial macroreentrant flutter post-atrial fibrillation ablation (n=89). Electroporation (pulsed-field ablation) vs. Radiofrequency ablation was evaluated on Arrhythmic recurrence (including atrial fibrillation and left atrial flutter) at final follow-up (p=0.008). Electroporation (pulsed-field ablation) significantly reduced arrhythmic recurrence at final follow-up compared to radiofrequency ablation (17.9% vs 44.0%, p=0.008).

synapsesocial.com/papers/6a3f97bb125782b61d86597bhttps://doi.org/10.1093/europace/euag105.605
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Results of pulsed field ablation for complex atrial tachycardia recurring after persistent atrial fibrillation ablation and resistant to prior radiofrequency ablation.2026
  2. 2Pulsed field ablation of atrial fibrillation in patients with reduced ejection fraction: an international, multicenter study2026
  3. 3Higher premature atrial contraction burden after radiofrequency ablation vs. pulsed field or cryoballoon ablation in paroxysmal atrial fibrillation: a 3-year follow-up retrospective study2025 · 1 citations
  4. 4Feasibility of mapping and ablation of atypical atrial flutter using a lattice-tip catheter toggling between radiofrequency and pulsed field energy2026
  5. 5Impact of pulse field versus radiofrequency on atrial fibrillation ablation workflow and organization: a single high volume center experience2026