What is the clinical evidence from this study?

Study design: Cohort. Population: Atrial fibrillation or left atrial tachycardia with obesity (n=325). Intervention: Severe obesity (BMI >40 kg/m²) vs. Obesity (BMI 30.0-39.9 kg/m²). Primary outcome: Bleeding events (OR 3.54, 95% CI 0.91-11.87, p=0.034).

What question did this study set out to answer?

This study aims to analyze ablation outcomes and anticoagulation management in patients with obesity or severe obesity and atrial fibrillation.

June 27, 2026EP EuropaceOpen Access

Ablation outcome and post-interventional management of anticoagulation in patients with obesity or severe obesity and atrial fibrillation

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Why the study?

Does severe obesity compared to moderate obesity affect ablation success and post-interventional anticoagulation outcomes in patients undergoing catheter ablation for atrial fibrillation?

Population

325 patients with obesity or severe obesity who underwent catheter ablation for atrial fibrillation or left…

Comparison

Catheter ablation and post-interventional… vs Catheter ablation and post-interventional…

Design

Cohort

Follow-up

up to 55 months

Key result

Severe obesity (BMI >40 kg/m²) was associated with a higher risk of bleeding events compared to obesity (BMI 30-39.9 kg/m²) after AF ablation (12.5% vs 3.9%; OR 3.54, 95% CI 0.91-11.87; p=0.034).

Authors

RBR Bares MTM Tydecks PBP Bicprendi

Discussion

Member takes

Overview

Severe obesity was associated with higher post-ablation bleeding; leaves open effects on AF recurrence and thromboembolism.

Key Points

This study aims to analyze ablation outcomes and anticoagulation management in patients with obesity or severe obesity and atrial fibrillation.
Retrospective single-center analysis of 1306 patients undergoing ablation for atrial fibrillation or tachycardia.
Patients categorized into two groups based on BMI: group 1 (30.0-39.9 kg/m²) and group 2 (>40 kg/m²).
Statistical analysis performed using RStudio.
39.3% experienced arrhythmia recurrence within 12 months, with no significant differences between groups (p = 0.586).
Bleeding events were significantly higher in severely obese patients (12.5% vs. 3.9%; p = 0.034).
No thromboembolic events occurred in patients with CHA2DS2-VA-Score <2 regardless of anticoagulation status.

Study Design

Type

Cohort (n=325)

Multicenter

Structured PICO

Does severe obesity compared to moderate obesity affect ablation success and post-interventional anticoagulation outcomes in patients undergoing catheter ablation for atrial fibrillation?

Population

325 patients with obesity or severe obesity undergoing catheter ablation for atrial fibrillation or tachycardia, followed for up to 55 months.

Exposure

Catheter ablation and post-interventional anticoagulation in severely obese patients (BMI >40 kg/m²)

Comparator

Catheter ablation and post-interventional anticoagulation in obese patients (BMI 30.0-39.9 kg/m²)

Outcome

Arrhythmia recurrence and incidence of thromboembolic and bleeding events

Main Result

Odds Ratio: 3.54 (95% CI 0.91–11.87)

Absolute Event Rate: 12.5% vs 3.9%

p-value: p=0.034

Severe obesity does not significantly impact AF ablation success or thromboembolic risk compared to moderate obesity, but is associated with a higher risk of bleeding events, suggesting careful consideration of post-ablation anticoagulation duration.

Cite This Study

Bares et al. (2026) conducted a cohort in Atrial fibrillation or left atrial tachycardia with obesity (n=325). Severe obesity (BMI >40 kg/m²) vs. Obesity (BMI 30.0-39.9 kg/m²) was evaluated on Bleeding events (OR 3.54, 95% CI 0.91-11.87, p=0.034). Severe obesity (BMI >40 kg/m²) was associated with a higher risk of bleeding events compared to obesity (BMI 30-39.9 kg/m²) after AF ablation (12.5% vs 3.9%; OR 3.54, 95% CI 0.91-11.87; p=0.034).

synapsesocial.com/papers/6a3f9785125782b61d865785 https://doi.org/10.1093/europace/euag105.399

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June 27, 2026EP EuropaceOpen Access

Ablation outcome and post-interventional management of anticoagulation in patients with obesity or severe obesity and atrial fibrillation

View Full Paper

Ask AI

Bookmark

Why the study?

Does severe obesity compared to moderate obesity affect ablation success and post-interventional anticoagulation outcomes in patients undergoing catheter ablation for atrial fibrillation?

Population

325 patients with obesity or severe obesity who underwent catheter ablation for atrial fibrillation or left…

Comparison

Catheter ablation and post-interventional… vs Catheter ablation and post-interventional…

Design

Cohort

Follow-up

up to 55 months

Key result

Severe obesity (BMI >40 kg/m²) was associated with a higher risk of bleeding events compared to obesity (BMI 30-39.9 kg/m²) after AF ablation (12.5% vs 3.9%; OR 3.54, 95% CI 0.91-11.87; p=0.034).

Authors

RBR Bares MTM Tydecks PBP Bicprendi

Discussion

Member takes

Overview

Severe obesity was associated with higher post-ablation bleeding; leaves open effects on AF recurrence and thromboembolism.

Key Points

This study aims to analyze ablation outcomes and anticoagulation management in patients with obesity or severe obesity and atrial fibrillation.
Retrospective single-center analysis of 1306 patients undergoing ablation for atrial fibrillation or tachycardia.
Patients categorized into two groups based on BMI: group 1 (30.0-39.9 kg/m²) and group 2 (>40 kg/m²).
Statistical analysis performed using RStudio.
39.3% experienced arrhythmia recurrence within 12 months, with no significant differences between groups (p = 0.586).
Bleeding events were significantly higher in severely obese patients (12.5% vs. 3.9%; p = 0.034).
No thromboembolic events occurred in patients with CHA2DS2-VA-Score <2 regardless of anticoagulation status.

Study Design

Type

Cohort (n=325)

Multicenter

Structured PICO

Does severe obesity compared to moderate obesity affect ablation success and post-interventional anticoagulation outcomes in patients undergoing catheter ablation for atrial fibrillation?

Population

325 patients with obesity or severe obesity undergoing catheter ablation for atrial fibrillation or tachycardia, followed for up to 55 months.

Exposure

Catheter ablation and post-interventional anticoagulation in severely obese patients (BMI >40 kg/m²)

Comparator

Catheter ablation and post-interventional anticoagulation in obese patients (BMI 30.0-39.9 kg/m²)

Outcome

Arrhythmia recurrence and incidence of thromboembolic and bleeding events

Main Result

Odds Ratio: 3.54 (95% CI 0.91–11.87)

Absolute Event Rate: 12.5% vs 3.9%

p-value: p=0.034

Cite This Study

synapsesocial.com/papers/6a3f9785125782b61d865785 https://doi.org/10.1093/europace/euag105.399

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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