What question did this study set out to answer?

This study aims to investigate the incidence and risk factors of central nervous system relapse in adult patients with acute lymphoblastic leukemia following hematopoietic cell transplantation.

June 27, 2026Blood AdvancesOpen Access

Incidence and Risk Factors for CNS Relapse in Adult ALL after Allogeneic Hematopoietic Cell Transplantation

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Authors

CLCatherine Thuy Khanh LeCornell University AZAmy ZhangPalo Alto University RVRutu D VyasFred Hutch Cancer Center

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Implication

Multicenter retrospective study reports CNS relapse rates and risk factors in adults with ALL post-HCT, suggesting implications for treatment strategies.

Key Points

This study aims to investigate the incidence and risk factors of central nervous system relapse in adult patients with acute lymphoblastic leukemia following hematopoietic cell transplantation.
Performed a multicenter retrospective analysis of 636 adults with ALL who underwent first HCT from 2011 to 2021.
Evaluated incidence of CNS relapse and risk factors, focusing on pre-HCT characteristics and conditioning regimens.
Assessed the association of CNS relapse with overall survival outcomes.
Cumulative incidences of CNS relapse were 3% at 1 year and 6% at 3 years after HCT.
Absence of CNS involvement before HCT, pre-HCT MRD negativity, and TBI-based conditioning were linked to reduced relapse risk (HR = 0.31, 95% CI, 0.15-0.68, p = 0.0032).
CNS relapse significantly shortened overall survival (HR 7.33, 95% CI, 5.12-10.49, p < 0.0001) with worse outcomes correlated with earlier relapse.

Cite This Study

Le et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f802 https://doi.org/10.1182/bloodadvances.2026020594

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Implication

Multicenter retrospective study reports CNS relapse rates and risk factors in adults with ALL post-HCT, suggesting implications for treatment strategies.

Incidence and Risk Factors for CNS Relapse in Adult ALL after Allogeneic Hematopoietic Cell Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Incidence and Risk Factors for CNS Relapse in Adult ALL after Allogeneic Hematopoietic Cell Transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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