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June 27, 2026Pediatric ResearchOpen Access

20/ (fasting C-peptide × fasting plasma glucose) as a novel marker for insulin resistance in obese children and adolescents

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Authors

DADoaa El AmrousySSSarah El ShallAHAhmed Hassan

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Overview

Case-control study evaluates a new index for insulin resistance in obese children, suggesting its diagnostic value.

Key Points

  • This study aims to evaluate the effectiveness of the 20/(fasting C-peptide × fasting plasma glucose) index in detecting insulin resistance in obese children and adolescents.
  • Case-control design including 100 children (50 obese, 50 controls), ages 6–16 years.
  • Measured fasting blood glucose, serum insulin, C-peptide, and lipid profiles to assess insulin resistance using HOMA-IR and other metabolic indicators.
  • Statistical evaluations included comparisons of metabolic parameters and correlation analyses.
  • Obese children showed significantly elevated BMI and levels of fasting C-peptide and HOMA-IR compared to controls.
  • The 20/(Fcpep × FBG) index was lower in obese children (0.10 ± 0.04 vs. 0.18 ± 0.05, p < 0.001).
  • Sensitivity of 86.67% and specificity of 85% for predicting insulin resistance at a cut-off ≤0.164.

Cite This Study

Amrousy et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f4ebhttps://doi.org/10.1038/s41390-026-05251-6
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